. Author manuscript; available in PMC: 2024 Mar 25.

Published in final edited form as: Cancer Causes Control. 2023 Nov 27;35(4):661–669. doi: 10.1007/s10552-023-01822-8

Table 2.

Hazard ratios (HRs) and 95% Confidence Intervals (95%CI) for liver cancer by blood DNA methylation markers in the Strong Heart Study

CpG site	Model 1		Model 2		Associated genes	Gene functions
CpG site	HR (95% CI)	p-value*	HR (95% CI)	p-value	Associated genes	Gene functions
cg16057201	1.25 (1.15, 1.36)	7.01E–08	1.25 (1.14, 1.37)	1.94E–06	MRFAP1	Cell growth
cg26804244	0.68 (0.58, 0.80)	3.69E–06	0.70 (0.59, 0.82)	2.57E–05
cg08550308	0.77 (0.68, 0.87)	1.90E–05	0.77 (0.67, 0.88)	1.01E–04
cg06778410	0.62 (0.47, 0.81)	6.08E–04	0.62 (0.47, 0.83)	1.04E–03
cg17739868	0.74 (0.67, 0.82)	2.87E–08	0.75 (0.67, 0.84)	8.17E–07
cg03928653	0.73 (0.63, 0.84)	1.91E–05	0.75 (0.65, 0.87)	8.75E–05
cg18854531	0.71 (0.60, 0.83)	4.36E–05	0.71 (0.60, 0.85)	1.28E–04
cg17519011	0.71 (0.58, 0.87)	1.11E–03	0.70 (0.56, 0.86)	8.06E–04	A4GALT	Globoside synthesis
cg04967787	0.53 (0.41, 0.70)	4.62E–06	0.58 (0.44, 0.75)	4.79E–05	PPRC1	Mitochondrial biogenesis

The HR is reported per SD of Beta for differential methylation markers

Model 1: age, sex, center, and immune cell proportions

Model 2: Model 1 + alcohol (never, ever, current), smoking (never, ever, current), BMI and LDL-cholesterol