Heterogeneous effect of genetic variants in lung cancer. A, forest plot of association in ever-, never-smoking and non-stratified analysis for new variant identified in the study. B, bar chart of lung cancer risk in never, light (pack year <= 20) and moderate to heavy smokers (packyear > 20) for variants with association in ever-smoking lung cancer in EUR. *, novel variants identified in this study. y-axis was truncated at 4. 95% error bars were plotted for each measurement. The variants are divided into four groups according to the risk pattern in different smoking groups.