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. Author manuscript; available in PMC: 2024 Feb 4.
Published in final edited form as: BJC Rep. 2024 Jan 23;2:4. doi: 10.1038/s44276-023-00035-5

Table 2.

The CDR3 regions of the top 5 TCRs from each group.

Sample % of total TCRs TCR β TCR α
7.7% CASSHDWG DNYAEQFF CAMREMDYNQGKLIF, CAMREMDYNQGKLIF, CAVKGFASALTF
4.1% CASSQGLGEDTQYF CAAKDYSNNRLTL
PBS 1.8% CASSQEMGTGGREGTQYF CAVSMSGSFNKLTF
1.4% CASSQTQGADTQYF CAARDYSNNRLTL
0.9% CASSFPGSSYEQYF CAASSNNNNAPRF
11.3% CASRTGDNYAEQFF CAVSDGSGYNKLTF
7.2% CASARTGGYEQYF, CASSEGTGGTPNSDYTF CALSDQGGSAKLIF
Anti-PD-1 5.9% CASSLELGGLEQYF CAVTPDYSNNRLTL
4.3% CAWSQQGRAEQFF, CGARDVGLGVPEQFF CAAEEESNNRIFF, CVLGLNNAGAKLTF
2.7% CASSLAGGSQNTLYF CAVSAKNNAGAKLTF
4.8% CASSQEGDGERLFF CAVSMTNTNKVVF, CAVSTENSGGSNAKLTF
1.9% CASSPGTGGYEQYF CASNTGYQNFYF
Ipilimumab 1.6% CASSQDIGWGVYAEQFF CALVADSNYQLIW
1.3% CASSLELGGPEQYF CAASDYSNNRLTL
0.6% CASSPQGAGTGQLYF CARGSNNRIFF, CAVSAG DYAQGLTF
5.7% CASSQEGDGNTLYF CALGENAPRF
4.3% CASSLGDRDTQYF, CASSPGTGGGTGQLYF CAGTNYNQGKLIF
D11 4.2% CASSLAWGGGANERLFF, CASSLEGGRKEQYF CATDTDYSNNRLTL
3.0% CASSLVGGRDTQYF CAVSMGNTNKVVF
3.0% CASGEPENTLYF CAMREASSGSWQLIF
15.3% CASRGTGGAWAEQFF CALVDLTTASLGKLQF
8.8% CASSPTGGGDTQYF CAVTKDYSNNRLTL
D11+anti-PD-1 6.4% CASSAPGGTETLYF CALSDYSNNRLTL
3.4% CASSSGANSDYTF CAMRELASSSFSKLVF
2.3% CASSLQANQDTQYF CAARANYGNEKITF

The TCR frequencies are summarized and TCR β and TCR α sequences are shown.

anti-PD-1 anti-programmed cell death protein-1, CDR3 complementarity-determining region 3, PBS phosphate-buffered saline, TCR T-cell receptor.