Skip to main content
. Author manuscript; available in PMC: 2010 Jul 14.
Published in final edited form as: ACS Med Chem Lett. 2010 Apr 8;1(1):9–13. doi: 10.1021/ml900005b

Figure 3.

Figure 3

Compound 1 yields apparent noncompetitive inhibition using global kinetic analysis (A) but is shown to actually be a colloidal aggregator using the detergent assay of Shoichet and co-workers13 (B); the presence of 0.01% Triton X-100 in the assay mixture almost fully alleviates the enzyme inhibition (see the Supporting Information for a full description of this method).