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. Author manuscript; available in PMC: 2011 May 5.
Published in final edited form as: J Neurosci. 2010 May 5;30(18):6387–6397. doi: 10.1523/JNEUROSCI.0764-10.2010

Figure 6. Norepinephrine depletion alters single unit figure rates across cortico-striatal circuits.

Figure 6

a) We found neurons in V. Striatum, D. Striatum, orbital frontal cortex (OFC), thalamus, and VTA that increased their firing rates following norepinephrine depletion (Type 1 Neurons), and neurons in each of these areas that decreased their firing rates following norepinephrine depletion (Type 2 Neurons). b) Treatment with αMT reduced the population firing rate observed in WT mice (n = 163; p*<0.001). c) Treatment with αMT significantly increased the population firing rate observed in NET-KO mice (n= 275; p*<0.001). d) WT mice displayed more Type 2 neurons than Type 1 neurons within each brain area investigated. e) NET-KO mice displayed a significantly decreased proportion of Type 2 neurons within V. Striatum, orbital frontal cortex, and VTA compared to WT mice (p*<0.001 for comparisons between genotype; see squares with pink highlights).