Table 4.
Multivariable linear regression analyses of the relation (β estimate and 95% confidence interval) of prenatal acetaminophen exposure with language outcomes on the MB-CDI at 2 years.
| Unadjusted a | Exposure | Stratified by Sex |
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|---|---|---|---|---|---|
| Outcome | Main Effect | Females | Males | ||
|
|
|
|
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| Vocabulary | 1st Trimester | −0.44 (−1.31, 0.43) | −0.66 (−2.18, 0.85) | −0.33 (−1.39, 0.73) | |
| 2nd Trimester | * | −0.69 (−1.24, −0.14) | −0.83 (−1.57, −0.09) | −0.51 (−1.34, 0.31) | |
| 3rd Trimester | ** | −1.95 (−3.26, −0.65) | −1.89 (−3.59, −0.19) | −2.05 (−4.09, 0.003) | |
| Entire Pregnancy | * | −0.41 (−0.74, −0.09) | −0.50 (−0.94, −0.05) | −0.33 (−0.79, 0.13) | |
|
|
|
|
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| Mean Length of Utterance | 1st Trimester | −0.005 (−0.02, 0.01) | −0.004 (−0.03, 0.02) | −0.01 (−0.02, 0.01) | |
| 2nd Trimester | † | −0.007 (−0.01, 0.001) | −0.01 (−0.02, 0.002) | −0.005 (−0.02, 0.01) | |
| 3rd Trimester | * | −0.02 (−0.04, −0.0004) | −0.02 (−0.05, 0.001) | −0.02 (−0.05, 0.02) | |
| Entire Pregnancy | † | −0.004 (−0.01, 0.001) | −0.005 (−0.01, 0.001) | −0.003 (−0.01, 0.004) | |
|
|
|
|
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| Complexity | 1st Trimester | −0.04 (−0.11, 0.02) | −0.05 (−0.16, 0.07) | −0.04 (−0.12, 0.03) | |
| 2nd Trimester | −0.02 (−0.07, 0.02) | −0.03 (−0.11, 0.06) | −0.02 (−0.08, 0.04) | ||
| 3rd Trimester | −0.04 (−0.15, 0.07) | −0.01 (−0.16, 0.14) | −0.08 (−0.26, 0.09) | ||
| Entire Pregnancy | −0.02 (−0.04, 0.01) | −0.02 (−0.06, 0.03) | −0.02 (−0.05, 0.01) | ||
|
|
|
|
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| Adjusted b | |||||
|
|
|
|
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| Vocabulary | 1st Trimester | −0.28 (−1.14, 0.58) | −0.48 (−1.97, 1.02) | −0.18 (−1.23, 0.87) | |
| 2nd Trimester | * | −0.58 (−1.13, −0.04) | −0.78 (−1.52, −0.05) | −0.33 (−1.16, 0.50) | |
| 3rd Trimester | ** | −1.83 (−3.13, −0.54) | −1.78 (−3.46, −0.11) | −1.91 (−3.93, 0.11) | |
| Entire Pregnancy | * | −0.35 (−0.67, −0.03) | −0.45 (−0.90, −0.01) | −0.24 (−0.70, 0.22) | |
|
|
|
|
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| Mean Length of Utterance | 1st Trimester | −0.002 (−0.01, 0.01) | −0.002 (−0.02, 0.02) | −0.003 (−0.02, 0.01) | |
| 2nd Trimester | † | −0.01 (−0.01, 0.001) | −0.01 (−0.02, 0.001) | −0.003 (−0.02, 0.01) | |
| 3rd Trimester | * | −0.02 (−0.04, −0.003) | −0.02 (−0.05, −0.001) | −0.02 (−0.06, 0.01) | |
| Entire Pregnancy | −0.004 (−0.01, 0.001) | −0.01 (−0.01, 0.001) | −0.002 (−0.01, 0.005) | ||
|
|
|
|
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| Complexity | 1st Trimester | −0.03 (−0.10, 0.03) | −0.04 (−0.15, 0.07) | −0.03 (−0.10, 0.05) | |
| 2nd Trimester | −0.02 (−0.07, 0.03) | −0.02 (−0.10, 0.06) | −0.01 (−0.07, 0.05) | ||
| 3rd Trimester | −0.04 (−0.15, 0.08) | −0.0003 (−0.15, 0.15) | −0.08 (−0.26, 0.09) | ||
| Entire Pregnancy | −0.01 (−0.04, 0.01) | −0.01 (−0.06, 0.03) | −0.01 (−0.05, 0.02) | ||
|
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a
Unadjusted models were adjusted for child sex and age.
b
All models were adjusted for child sex and age at assessment, maternal parity, maternal education, mean perceived stress during pregnancy, and mean depression during pregnancy.
†
p < 0.10,
*
p < 0.05,
**
p < 0.01