Table 6.
Multivariable linear regression analyses of the relation (β estimate and 95% confidence interval) of prenatal acetaminophen exposure with language outcomes on the SLAS at 3 years.
| Unadjusted a | Stratified by Sex |
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|---|---|---|---|---|---|---|
| Exposure | Main Effect | Females | Males | |||
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| 1st Trimester | † | −0.07 (−0.16, 0.01) | −0.12 (−0.27, 0.03) | −0.05 (−0.15, 0.06) | ||
| 2nd Trimester | * | −0.06 (−0.11, −0.01) | −0.09 (−0.15, −0.02) | −0.03 (−0.10, 0.05) | ||
| 3rd Trimester | ** | −0.18 (−0.29, −0.06) | ‡ | −0.08 (−0.24, 0.08) | ** | −0.29 (−0.45, −0.12) |
| Entire Pregnancy | ** | −0.04 (−0.07, −0.01) | −0.05 (−0.09, −0.01) | −0.04 (−0.08, 0.01) | ||
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| Adjusted b | ||||||
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| 1st Trimester | −0.04 (−0.13, 0.04) | −0.11 (−0.25, 0.04) | −0.01 (−0.11, 0.09) | |||
| 2nd Trimester | † | −0.04 (−0.09, 0.01) | −0.07 (−0.14, −0.01) | −0.002 (−0.08, 0.07) | ||
| 3rd Trimester | ** | −0.15 (−0.26, −0.04) | § | −0.04 (−0.198, 0.11) | ** | −0.27 (−0.43, −0.11) |
| Entire Pregnancy | * | −0.03 (−0.06, −0.001) | −0.04 (−0.08, 0.001) | −0.02 (−0.07, 0.02) | ||
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a
Unadjusted models were adjusted for child sex and age.
b
All models were adjusted for child sex, maternal education, mean perceived stress during pregnancy, and mean depression during pregnancy.
Interaction p-values:
‡
p<0.10,
§
p<0.05
*
p < 0.05,
**
p < 0.01