Kaplan-Meier curves stratified by median downward creep adjusted by following variables: age, sex, body mass index, hypertension, hyperlipidemia, diabetes, smoking, prior history of coronary artery disease, cerebral stroke, peripheral vascular disease, anginal chest pain, shortness of breath, early revascularization, stress TPD, rest TPD, stress-rest change in LVEF, rest LVEF, rest LVEDV, heart rate response, systolic BP response, diastolic BP response, and myocardial flow reserve. BP, blood pressure; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; TPD, total perfusion deficit