TABLE 1.

Digital brain health monitoring platform: technology use and data description.

	Technology	Platform	Measures	Participant schedule	Assessment frequency	Compliance tracking	Data upload
Active engagement application	Linus participant	Smartphone	Cognition, speech, gait and balance, questionnaires	Complete 25min series of tasks once remotely	Quarterly	Daily	Automatic upload (w Internet)
	Lumosity	Smartphone, computer	Cognition	Complete 5 tasks (15min) remotely	Quarterly	Bi-weekly	Automatic upload (w Internet)
	Mezurio	Smartphone	Cognition, speech, motor function	Complete 10min of tasks daily for 2 weeks remotely	Quarterly	Daily	Automatic upload (w Internet)
Passive engagement application	Longevity	Smartphone	Motor function	Data collected continuously in the background	Continuousx	Weekly	Automatic upload (w Internet)
	NeuraMetrix typing cadence application	Computer (PC Only)	Cognition, motor function	Data collected continuously in the background	Continuousx	Daily	Automatic upload (w Internet)
Activity wearable	Fitbit charge 4	Wrist-worn device, smartphone	Physical activity, heart rate, sleep	Wear wrist device day and night for 2 weeks	Quarterly	Daily	Automatic upload (w Internet and Bluetooth)
	Wrist-worn wearable	Wrist-worn device	Physical activity, sleep	Wear wrist device day and night for 2 weeks	Quarterly	One time upload**	Manual upload by staff
Sleep wearable	Dreem3 headband	Head-worn device, Smartphone	Sleep movement, respiration, EEG	Wear sleep headband for 3 or more nights	Quarterly	Daily	Automatic upload (w Internet) when charging
	SleepImage	Finger-worn device, Smartphone, cloud-computing	ANS-based sleep evaluation, pulse oximetry, respiration, sleep	Wear sleep ring for 3 or more nights	Quarterly	Daily	Automatic Upload (w Internet and Bluetooth)
Staff-guided technology	APDM mobility lab*	Wearable sensor system	Motion, gait and balance metrics	Complete set series of tasks in person	Annually	Not applicable	Staff guided after assessment
	Linus tester*	Tablet	Digital pen movement, multi-domain cognition	Complete set series of tasks in person	Annually	Not applicable	Staff guided after assessment
	Digital voice recorder*	Voice recorder	Voice	Complete picture description and recall in person or remotely	Annually	Not applicable	Staff guided after assessment

^*Device used during staff-guided assessments. Gait and balance sensors and tablet-based assessment are used only during in-clinic visits. Digital voice recorder is used during staff-guided in-clinic and remote visits.

^**The wristband continuously collects data from an embedded accelerometer after study staff links the device to a study-based smartphone. Then, the collected data is uploaded manually to an Amazon Web Services (AWS) backend when the technology is returned to the study site.

^xContinuous smartphone and computer tracking entails the capture of typing speed and usage data whenever a participant uses their personal device.