Extended Data Fig. 8 |.

Cognitive outcomes are predicted by the biological link between LC and MTL tau burden. A higher correlation between LC-related - MTL tau accumulation was associated with lower cognitive performance as measured by the PACC 5 (z-scores) approximately three years later (n = 77 independent individuals). The plot reflects the relationship between the averaged left and right MTL tau deposition and PACC5 z-scores adjusted by age, sex, years of education and CDR (robust linear regression, two-tailed analysis). Dots represent the estimates (beta-coefficients) of the relationships tested and the shaded areas around the fit lines show 95% CI Abbreviations: FTP = 18-flortaucipir PET; LC=locus coeruleus; MTL=medial temporal lobe; PACC5=Preclinical Alzheimer’s disease Cognitive Composite 5; p = p value; PVC=partial volume corrected; SUVR=standardized uptake value ratio.