Extended Data Fig. 9 |.

Cognitive outcomes are not associated with the reverse hypothesized pathway ‘follow-up LC-related – baseline MTL tau deposition’. (A) Left MTL (n = 74 independent individuals). (B) Right MTL (n = 74 independent individuals). The possible association between tau deposition in the MTL at baseline with LC integrity (inverted signal) years later does not predict lower cognitive performance on the PACC5 (z-scores). The plots are adjusted by age, sex, years of education and CDR (robust linear regression, two tailed analysis). In all plots, dots represent the estimates (beta-coefficients) of the relationships tested and the shaded areas around the fit lines show 95% CI. Abbreviations: FTP = 18-flortaucipir PET; MTL=medial temporal lobe; p = p value; PACC5=Preclinical Alzheimer’s Cognitive Composite 5; PVC=partial volume correction; SUVR=standardized uptake value ratio.