. Author manuscript; available in PMC: 2024 Jun 21.

Published in final edited form as: ACS Chem Neurosci. 2024 Jun 7;15(12):2396–2407. doi: 10.1021/acschemneuro.4c00086

Table 3.

In Vivo and In Vitro Results of Selected Compounds

compound	f _u,plasma ^a		CL_H^a (mL/min/kg)		CL_p^a (mL/min/kg)	t_1/2^a (h)	V_ss^a (L/kg)	AUC^a (h·ng/mL)
	human	rat	human	rat
4	0.01	0.03	16.9	59.1	116	1.05	5.52	28.7
33	0.19	0.26	16.0	39.0	123	4.02	36.9	27.0
32	0.06	0.14	14.7	46.2
29	0.05	0.15	17.3	49.2
20	0.10	0.23	13.7	36.2	126	4.55	44.4	26.4

f_u = Fraction unbound; equilibrium dialysis assay; CL_H = hepatic clearance; CL_p = plasma clearance; t_1/2 = terminal phase plasma half-life; V_ss = volume of distribution at steady-state; AUC = area under the curve.