Skip to main content
. Author manuscript; available in PMC: 2010 Oct 28.
Published in final edited form as: J Neurosci. 2010 Apr 28;30(17):5843–5854. doi: 10.1523/JNEUROSCI.0137-10.2010

Figure 6.

Figure 6

Synergism between fibrinogen and active TGF-β in the induction of astrogliosis and neurocan deposition. A, Fib−/− mice show reduced astrogliosis and neurocan expression demonstrated by immunostaining for GFAP and neurocan, 3 days after TGF-β injection followed by SWI. Uninjured WT mice served as controls. Stereotactic injection of TGF-β induced a similar increase in astrogliosis and neurocan expression in Fib−/− and WT controls injected with ACSF. B, Quantification revealed significant lower levels of GFAP and neurocan in Fib−/− mice than in WT mice (n=4 per group) after TGF-β injection and SWI. Values are mean ± SEM. *p < 0.001. Scale bar, 90 μm.