Table 5.

Dual stain triage of HPV-positive NILM, ASC-US, or LSIL cytology results in a co-testing setting in KPNC

Current Test Result	N	% of Total	CIN3+ Cases	CIN3+ Immediate Risk (%)	CIN3+ 3-year Cumulative Risk (%)	Clinical management recommendation	Management Confidence Probability%
HPV+/NILM/DS+	1,003	1.4	73	4.6	8.6	colposcopy	79
HPV+/NILM/DS−	1,864	2.7	20	0.60	1.5	1-year return	100
HPV+/ASC-US/DS+	978	1.0	82	6.6	9.9	colposcopy	100
HPV+/ASC-US/DS−	954	1.0	15	0.87	1.6	1-year return	100
HPV+/LSIL/DS+	942	0.9	46	4.1	5.9	colposcopy	58
HPV+/LSIL/DS−	595	0.6	7	0.53	0.92	1-year return	100

Abbreviations: HPV, human papillomavirus; DS, dual stain; KPNC, Kaiser Permanente Northern California; CIN3+, cervical intraepithelial neoplasia grade 3 or worse; yr, year; NILM, negative for intraepithelial lesion or malignancy; ASC-US, atypical squamous cells of undetermined significance; LSIL, low grade intraepithelial lesion; +, positive; −, negative