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Histograms of relative abundance values for wt-TTR, mTTR, and hTTR tetramers present in 35 °C solutions initially containing wt-TTR and (A) L55P, (B) V30M, (C) F87A, and (D) T119M homotetramers. The relative abundance values show evidence that, in many cases, hTTR formation is hindered at 35 °C, which we interpret to mean that hydration plays a role in SUE.
