Table 1.

Requirements for Resolving and Quantifying hTTR Tetramers Containing mTTR and wt-TTR Subunits

mutant	average monomer mass (Da)	average tetramer mass (Da)	Δmass of tetramer from wt-TTR (Da)	Δmass of monomer from wt-TTR (Da)	Δm/z shift for each hTTR state (16+ CS)	resolving power needed to separate hTTR tetramers
WT	13906	55622	NA	NA	NA	NA
L55P	13889	55558	−64.20	−16.05	−1.00	3462
V30M	13938	55750	128.24	32.06	2.00	1739
F87A	13829	55318	−304.40	−76.10	−4.76	727
T119M	13936	55742	120.32	30.08	1.88	1853