Table 2. Toxicities (n=51).
| Grade (% of patients) | ||||
|---|---|---|---|---|
| Toxicity | 1 | 2 | 3 | 4 |
| Adrenal insufficiency | - | 1 (2) | 1 (2) | - |
| Anemia | 28 (55) | 14 (27) | 4 (8) | 1 (2) |
| Colitis | - | 1 (2) | 3 (6) | 1 (2) |
| Confusion | - | - | 3 (6) | 1 (2) |
| Conjunctivitis | - | 2 (4) | - | - |
| Dehydration | - | - | 3 (6) | - |
| Diarrhea | 6 (12) | 3 (6) | 8 (16) | - |
| Dyspnea | 9 (18) | 4 (8) | 4 (8) | 1 (2) |
| Fatigue | 17 (33) | 9 (18) | 4 (8) | - |
| Hypothyroidism | - | 1 (2) | - | - |
| Increased ALT | 9 (18) | 5 (10) | 2 (4) | 2 (4) |
| Increased AST | 11 (22) | 4 (8) | 2 (4) | 2 (4) |
| Increased bilirubin | - | - | 2 (4) | 2 (4) |
| Increased lipase | 1 (2) | - | - | 1 (2) |
| Infection | - | - | 3 (6) | 2 (4) |
| Leukopenia | 10 (20) | 1 (2) | - | 1 (2) |
| Lymphopenia | 6 (12) | 9 (18) | 9 (18) | - |
| Nausea/vomiting | 15 (29) | 4 (8) | 2 (4) | - |
| Neutropenia | - | - | - | 1 (2) |
| Pain | 10 (20) | 8 (16) | 2 (4) | - |
| Pruritis | 18 (35) | 4 (8) | - | - |
| Rash | 13 (25) | 5 (10) | 1 (2) | - |
| Thrombosis | - | - | 1 (2) | 1 (2) |
| Thrombocytopenia | 1 (2) | 2 (4) | 2 (4) | 1 (2) |
ALT, alanine aminotransferase; AST, aspartate aminotransferase