Table 3. Clinical characteristics of patients with objective responses.
Age/sex | Baseline LDH | No. of prior therapies | Disease sites | Best response | Time-to-response (mos) | Response duration (mos) | OS (mos) |
---|---|---|---|---|---|---|---|
76/M | 113 | 3 | Lung, soft tissue | irCRa | 3.5 | 10.2+ | 13.7+ |
78/F | 160 | 3 | Lung, soft tissue, bone | irPR | 2.4 | 2.8 | 8.3 |
62/M | 92 | 4 | Soft tissue | irCRb | 5.2 | 6.2+ | 11.4+ |
66/M | 121 | 2 | Lung, soft tissue, lymph node | irCR | 5.6 | 5.6+ | 11.2+ |
62/M | 171 | 3 | Lung, lymph node | irPR | 4.3 | 6+ | 10.3+ |
47/M | 210 | 1 | Lymph node | irCRc | 2.6 | 4.4+ | 7.0+ |
CR, complete response; LDH, lactate dehydrogenase; mos, months; OS, overall survival; PR, partial response
This patient experienced a CR to ipilimumab and surgery;
This patient received radiotherapy prior to study entry;
This patient was found to have achieved a pathologic CR when the only metastatic site was resected.