Figure 2:

Functional annotation results for each SNP in the region of rs77196339. A. Epigenetic annotations including maximum ENCODE H3K27ac level over 14 cell lines, maximum H3K4me1 level, and maximum H3K4me3 level. Higher values strongly imply the region regulates transcription processes. Red dot is epigenetic principal component integrating three plotted individual scores and four other epigenetic annotations.²⁷ Dotted vertical represents top SNP location. B. Evolutionary conservation annotations including primate, mammal, and vertebrate PhyloP scores as well as primate and mammal phastCons scores. Higher values imply the region is more conserved across each phylogenetic tree. Red dot is evolutionary conservation principal component integrating five plotted individual scores and three similar conservation annotations.²⁷