Table 1.

Total area of drusen (in mm²) within a 3.11mm² macular study area is reported for each imaging modality for all 12 subjects. To aid the reader, the area of drusen expressed as a percentage of the study area is reported for one set of results (Column 1, SD OCT 2D Interpolation). For the SD OCT drusen map, drusen markings on a series of 100 B-scans across the macula were projected onto an SVP retinal image with interpolation of spaces between sequential scans to produce a map of drusen marking by SD OCT (see Figures 1, 2). The automated CFP map utilized a drusen detection algorithm to identify drusen on an enhanced, background-leveled CFP image (see Figure 3). Additionally, three retinal specialists independently graded CFPs for drusen. The composite CFP map includes all areas marked as drusen by at least 2 of 3 graders (see Figure 2). (SD = standard deviation)

	SD OCT			CFP
	2D Interpolation		NWE Interpolation	Automated	Composite	Grader 1	Grader 2	Grader 3
Eye	mm2	(%)	mm2	mm2	mm2	mm2	mm2	mm2
1	0.3	(9)	0.2	0.5	0.5	0.6	0.5	0.5
2	0.6	(19)	0.6	0.8	0.8	0.9	0.9	1.0
3	0.6	(19)	0.6	0.6	0.6	0.4	0.6	0.7
4	0.7	(22)	0.7	0.6	0.6	0.8	0.6	0.7
5	0.7	(23)	0.7	0.9	1.0	1.0	1.0	1.0
6	0.9	(29)	0.9	0.7	0.8	1.0	0.7	1.1
7	1.0	(32)	1.0	0.7	0.9	1.4	0.9	0.7
8	1.2	(39)	1.2	0.9	1.1	0.9	1.2	1.3
9	1.8	(58)	1.9	1.6	1.4	1.6	1.2	1.4
10	2.3	(75)	2.4	1.9	2.0	2.0	2.0	1.9
11	2.3	(73)	2.4	2.3	1.8	1.9	1.7	1.9
12	3.0	(95)	3.0	2.7	3.1	3.1	2.2	3.1
Mean	1.3	(41)	1.3	1.2	1.2	1.3	1.1	1.3
SD	0.9	(28)	0.9	0.8	0.8	0.8	0.6	0.7