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Prepro-endothelin (ET)-1 overexpression increases ET-1 release in ovine fetal pulmonary arterial endothelial cells (FPAECs). Ovine fetal FPAECs were transfected with an expression plasmid for Prepro-ET-1 (pEGFP-N1-Prepro-ET-1) or the parental plasmid as a control. After 24 h, ET-1 levels in the culture medium was determined by ELISA. ET-1 levels are significantly higher in cells overexpressing Prepro-ET-1. Data are mean ±SD. *p <0.05 versus control, n = 3.
