Table 1.

Evidence-based rating system used in the Hematopoietic Cell Transplantation (HCT) Guidelines [2]

Strength of Recommendation
Category	Definition
A	Both strong evidence for efficacy and substantial clinical benefit support recommendation for use. Should always be offered
B	Moderate evidence for efficacy—or strong evidence for efficacy, but only limited clinical benefit—supports recommendation for use. Should generally be offered.
C	Evidence for efficacy is insufficient to support a recommendation for or against use, or evidence for efficacy might not outweigh adverse consequences, (e.g., drug toxicity, drug interactions), or cost of the chemoprophylaxis or alternative approaches. Optional.
D	Moderate evidence for lack of efficacy or for adverse outcome supports a recommendation against use. Should generally not be offered.
E	Good evidence for lack of efficacy or for adverse outcome supports a recommendation against use. Should never be offered.

Quality of Evidence supporting the recommendation
Category	Definition
I	Evidence from at least one well-executed randomized, controlled trial
II	Evidence from at least one well-designed clinical trial without randomization; cohort or case-controlled analytic studies (preferably from more than one center); multiple time-series studies; or dramatic results from uncontrolled experiments
III	Evidence from opinions of respected authorities based on clinical experience, descriptive studies, or reports of expert committees