Pathogen: Bacterial infections beyond 100 days post-HCT

Indication	First Choice	Alternatives
Prevention of late bacterial infections with antibiotic prophylaxis	Prolonged antibiotic prophylaxis is recommended only for preventing infection with S. pneumoniae among allogeneic recipients with cGVHD (see below).
Prevention of late bacterial infections with vaccinations	Immunizations (Table 6) are recommended for preventing infection with S. pneumoniae and H. influenzae type b
Prevention of bacterial infections among HCTrecipients with severe hypogammaglobulinemia (ie, serum IgG level <400 mg/dL)	IVIG, 500 g/kg every 3–4 weeks (CIII)	None

IVIG indicates intravenous immunoglobulin; HCT, hematopoietic cell transplantation; cGVHD, chronic graft-versus-host disease.

Notes: See the note in the previous table for IVIG administration for IgA-deficient patients.