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. Author manuscript; available in PMC: 2010 Jun 2.
Published in final edited form as: Viruses. 2010 Jan 28;2(2):372–394. doi: 10.3390/v2020372

Figure 3.

Figure 3

Positioning of RT with respect to the 3’-end of the primer. The pre-translocation complex places the RT active site in position to carry out excision with ATP or PPi as acceptor substrate. The primer terminus occupies the dNTP-binding site (N site) on RT. RT is stabilized in this position by binding PFA. The post-translocated complex places the RT in a position to add the next deoxynucleotide. The primer terminus occupies the primer-binding site (P site) on RT. RT is stabilized in this position by binding the next complementary dNTP [38,45–47,87]. The template and primer are shown in blue and green, respectively. The three orange dots correspond to active site catalytic residues, which are located near the boundary between the N and P sites.