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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Neuropsychopharmacology. 2010 Jan;35(1):86–104. doi: 10.1038/npp.2009.126

Figure 3.

Figure 3

A proposed functional organization of the medial temporal lobe memory system (Eichenbaum et al, 2007). Neocortical input regarding the object features (‘what’) converges in the perirhinal cortex (PRC) and lateral entorhinal area (LEA), whereas details about the location (‘where’) of objects converge in the parahippocampal cortex (PHC) and medial entorhinal area (MEA). These streams converge in the hippocampus, which represents items in the context in which they were experienced. Reverse projections follow the same pathways back to the parahippocampal and neocortical regions. Back projections to the PHC–MEA may support recall or context, whereas back projections to the PHC–LEA may support recall of item associations.