TABLE 2.
Genetic interactions between dVHL and Rab5 in the lumen formation phenotypea
| Genotype | No. of embryos | % normal | % with dorsal trunk lumen phenotype (convoluted + dilated) |
|---|---|---|---|
| UAS-lazZ/+; UAS-dVHLi, btl-GAL4/+ | 24 | 63 | 37 |
| UAS-YFP::Rab5wt/+; UAS-FLP, btl-GAL4/+ | 16 | 100 | 0 |
| UAS-YFP::Rab5wt/+; UAS-dVHLi, btl-GAL4/+ | 18 | 61 | 39 |
| UAS-YFP::Rab5CA/+; UAS-FLP, btl-GAL4/+ | 17 | 100 | 0 |
| UAS-YFP::Rab5CA/+; UAS-dVHLi, btl-GAL4/+ | 23 | 87 (A*) | 13 (A*) |
| UAS-YFP::Rab5DN/+; UAS-FLP, btl-GAL4/+ | 17 | 76 | 24 |
| UAS-YFP::Rab5DN/+; UAS-dVHLi, btl-GAL4/+ | 21 | 33 (B*) | 67 (B*) |
UAS-lacZ and UAS-FLP are used as neutral UAS transgenes for normalizing the effective Gal4 protein dosage. Statistical analyses used two-sample t tests for percentages.
modest significance (P < 0.1);
P = 0.065;
P = 0.066.