Target	Biologic Agent	Manufacturer	Composition	Reference
Cell Surface
CD4	Keliximab	SmithKline Beecham Pharmaceuticals	Chimeric IgG1 monoclonal antibody	[9-10]
CD23	IDEC-152	Biogen IDEC	Chimeric IgG1 monoclonal antibody	[11]
CD25	Daclizumab	Roche	Humanized IgG1 monoclonal antibody	[12]
IL-4Rα	Pitrakinra	Aerovance	15 kDa recombinant human IL-4 variant that is an antagonist of both IL-4 and IL-13 receptor binding	[21]
	AMG 317	Amgen	Fully human IgG2 monoclonal antibody	[22]
IL-5R	MEDI-563	MedImmune	Humanized IgG1 monoclonal antibody with enhanced antibody- dependent cellular cytotoxicity function	[32]
Soluble
IgE	Omalizumab	Genentech and Novartis	Humanized IgG1 monoclonal antibody	[14]
IL-4	Nuvance	Immunex	Soluble IL-4 receptor	[3]
IL-4	Pascolizumab	Glaxo Smith Kline and Protein Design Labs	Humanized IgG1 monoclonal antibody	[5]
IL-5	Mepolizumab	Glaxo Smith Kline	Humanized IgG1 monoclonal antibody	[23]
IL-9	MEDI-528	MedImmune	Humanized IgG1 monoclonal antibody	[27]
TNF α	Golimumab	Centocor/Schering- Plough	Fully human IgG1 monoclonal antibody	[8]
	Infliximab	Centocor Ortho Biotech	Chimeric IgG1 monoclonal antibody	[7]
	Etanercept	Immunex/Amgen	IgG1 fusion protein containing the extracellular domain of the p75 TNF receptor	[6]