Table 5.
Diagnostic properties of different models for a URI symptom score to differentiate symptomatic children in whom a respiratory virus was identified from those in whom no viral etiology was detected.
| Model | Sensitivity (95% CI) |
Specificity (95%CI) |
Accuracy (95%CI) |
PPV (95% CI) |
NPV (95% CI) |
Cut-off value‖ |
|---|---|---|---|---|---|---|
| Model 1* | 86.4 (75.0, 94.0) |
50.0 (34.2, 65.8) |
71.3 (61.4, 79.9) |
70.8 (58.9, 81.0) |
72.4 (52.8, 87.3) |
1 |
| Model 2** | 73.2 (59.7, 84.2) |
56.1 (39.7, 71.5) |
66.0 (55.7, 75.3) |
69.5 (56.1, 80.8) |
60.5 (43.4, 76.0) |
3 |
| Model 3§ | 81.4 (69.1, 90.3) |
61.9 (45.6, 76.4) |
73.3 (63.5, 81.6) |
75.0 (62.6, 85.0) |
70.3 (53.0, 84.1) |
2 |
| Model 4¶ | 94.3 (80.8, 99.3) |
16.7 (5.6, 34,7) |
58.4 (45.6, 70.6) |
56.9 (43.2, 69.8) |
71.4 (29.0, 96.3) |
14 |
Model 1 included the following symptom measures: significant runny nose day 1, significant runny nose day 4, significant cough day 4, any fever day 3.
Model 2 included the following symptom measures: significant runny nose day 1 – day 4, significant cough day 1 – day 4, any fever day 1 – day 4.
Model 3 included the following symptom measures: significant runny nose day 1 – day 4, significant cough day 1 – day 4.
Model 4 is based on the sum of the severity (rated 0–3) for the following symptoms for 6 days: sneezing, headache, chilliness, malaise, runny nose, nasal congestion, cough and sore throat (Jackson score).(8)
one point was given for the presence of each symptom measure present and points summed for each child. The cut-off value was the score that best differentiated children with and without a viral URI.