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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: J Neurosci. 2010 Jul 28;30(30):10187–10198. doi: 10.1523/JNEUROSCI.2268-10.2010

Figure 3. Repeated ethanol administration results in an increase in contribution of NR2B subunits to the activity of the channel in the DMS.

Figure 3

A, Time course of NMDAR EPSCs in DMS neurons from ethanol- and saline-treated rats before and during bath application of the NR2B-NMDAR-specific antagonist, Ro 25-6981 (0.25 μM) (as indicated by the horizontal line). Rats received injections of ethanol (2 g/kg, i.p.) or saline once a day for 7 days. DMS slices were prepared 16 hrs after the last injection. n = 17 (saline) and 15 (ethanol) slices. B, Summary of the mean inhibition magnitude of NMDAR-EPSCs by Ro 25-6981 in DMS neurons from saline- and ethanol-treated animals. *P < 0.05, t-test.