Figure 4. Attenuation of oxidative damage by trimetazidine(TMZ) treatment.
(A) DCF staining of frozen heart tissue sections from each group suggests that treatment with trimetazidine reduced the ROS generation in db/db mice hearts. DCF staining quantification is expressed as a percentage of relative grayscale value. bP<0.05 compared to C57 group; eP<0.05 compared to db/db group. (B) Malondialdehyde (MDA) levels in heart homogenates from TMZ-treated groups were markedly reduced compared to the db/db group. bP<0.05 compared to the C57 group; eP<0.05 compared to the db/db group.