Table 1.
In vivo hemodynamic characterization of C57, db/db, TMZ-low, and TMZ-high mice. Data shown represent the mean±SEM for control (C57, n=8), diabetic (db/db, n=10), low-dose TMZ-treated (TMZ-low, n=6) and high-dose TMZ-treated (TMZ-high, n=6) mice.
| C57 | db/db | TMZ-low | TMZ-high | |
|---|---|---|---|---|
| Heart rate (beat/min) | 300±8.05 | 356±21.7b | 283±16.2e | 295±8.12e |
| Maximum volume (µL) | 18.1±0.39 | 14.3±0.22b | 14.9±0.42b | 16.7±0.65be |
| LVESP (mmHg) | 94.6±2.33 | 129±2.42b | 115±7.44be | 112±3.42be |
| LVEDP (mmHg) | 5.76±0.32 | 124±3.31b | 110±7.10be | 108±4.20be |
| LVEDP (mmHg) | 5.76±0.32 | 10.4±0.92b | 7.63±0.67e | 7.89±0.96e |
| Stroke volume (µL) | 3.86±0.14 | 3.00±0.15b | 3.35±0.21 | 3.98±0.11e |
| Cardiac output (µL/min) | 735±41.9 | 559±30.0b | 775±63.0e | 739±24.0e |
| dp/dtmax (mmHg/s) | 3190±278 | 7440±434b | 6730±488b | 6270±525b |
| dp/dtmin (mmHg/s) | −2860±101 | −4040±324b | −4160±181b | −3990±364b |
Hemodynamic parameters were measured with a cardiac catheter tip manometer advanced from the right carotid artery via the aortic arch into the left ventricle. LVESP, LV end systolic pressure; LVEDP, LV end diastolic pressure; dp/dtmax and dp/dtmin, positive and negative first derivative of LV contraction and relaxation, respectively.
b
P<0.05 compared to the C57 mice group.
e
P<0.05 compared to the db/db mice group.