Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The early intrinsic events in the initiation of signaling are affinity dependent. The BCR transitions reversibly between free, antigen bound and oligomerized states (from left to right). These states are highly sensitive to the affinity of the BCR for antigen. High affinity BCRs are readily driven to oligomers whereas low affinity receptors only inefficiently oligomerize.
