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Values for kinetic parameters of the chymotrypsin-like activity of the proteasome in the presence of different concentrations of oligomeric Aβ(1–42) peptides.
| A beta (µM) |
KM.obs (µM) |
Ki (µM) |
Vmax (x10−2µM/min) |
|---|---|---|---|
| 0 | 5.9 ± 0.8a | 3.1 ± 0.1 | |
| 0.5 | 8.4 ± 1.3 | 1.2 | 3.1 ± 0.1 |
| 1 | 20 ± 4.2 | 0.4 | 3.5 ± 0.2 |
| 5 | 38 ± 9.1 | 0.9 | 3.7 ± 0.3 |
KM.obs equals the apparent KM of the LLVY-AMC substrate when no Aβ is present.
