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. Author manuscript; available in PMC: 2010 Nov 26.
Published in final edited form as: Oncotarget. 2010 Sep 1;1(5):329–338. doi: 10.18632/oncotarget.165

Figure 1. CD277 shares sequence and structural similarity with other members of the B7 superfamily of costimulatory molecules.

Figure 1

(A) Alignment of CD277 and B7-H4. Conserved cysteine residues are highlighted in red. Conserved Amino Acid regions are highlighted in black. (B) Cluster analysis of B7 superfamily members. The Amino Acid sequence of CD277 was aligned to other B7 superfamily members and a similarity tree was generated. (C) (left and center) Presentation of the CD277 and B7-H4 structures, predicted using the know structure of PD-L1 as a model, based on sequence. (right) Schematic overlay of both predicted structures. Blue, CD277; Orange, B7-H4.