Table 2.

Components of the Tennessee Children’s Respiratory Initiative enrolment visit, and each follow-up contact.

	Enrolment	1 to 2 Year Old Well child follow-up visit	Year 1 – Year 3	Year 4 – Year 5	Year 6 follow-up
	0–12 month old term, non low birth weight otherwise healthy infant enrolled at the time of a respiratory viral illness*	2 year well-child visit conducted in the CRC† or during home visit	Phone contact	Phone contact	Phone contact
Time line	Sept-May 2004–2008	2005–2009	2005–2011	2008–2012	2010–2014
Maternal skin testing‡	✓
Questionnaire and chart review	✓
Administration of structured phone questionnaire				✓	✓
Infant nasal and throat swab for viral identification	✓
Infant urine specimen	✓
Family history, including detailed atopic history	✓
Infant nasal epithelium (for cell culture repository)		✓
Child serum IgE and allergen specific IgE determination		✓
Infant DNA	✓ (or)	✓
Maternal DNA	✓ (or)	✓
Routine phone/mailing contact		✓	✓	✓	✓
		Every 12–18 months

^#These infant-mother dyads were recruited and enrolled at Vanderbilt Children’s Hospital (VCH), VCH pediatric emergency department, and VCH pediatric acute care clinic.

^†Clinical Research Center

^‡Allergen specific IgE (Phadiatop) is performed if unable to perform prick skin testing or negative histamine/positive control