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. Author manuscript; available in PMC: 2012 Aug 13.
Published in final edited form as: Traffic. 2008 Oct 14;9(12):2032–2042. doi: 10.1111/j.1600-0854.2008.00833.x

Figure 2.

Figure 2

The TRAPP I–Ypt1p interface. Ypt1p–TRAPP I contact regions span three TRAPP I subunits as revealed by the Ypt1p–TRAPP I complex recently reported by Cai et al. (18). A) Ribbon diagram of the Ypt1p–TRAPP I complex. B) A 90° rotated view relative to that shown in A). The orientation is similar to that shown in Cai et al. C) A close-up view showing the important putative interactions between TRAPP I and Ypt1. To demonstrate the incompatibility between the C-terminal region (wedge) of Bet3p-A with the presence of nucleotide on Ypt1p when in complex with TRAPP, a GTP analog (GppNHp) was docked to the Ypt1p–TRAPP I complex based on its position in the structure of Ypt1p-GTP (PDB ID 1YZN). Note how residues from the C-terminus of Bet3p-A occupy a similar position to that of the phosphate groups of the nucleotide. Figure prepared with Molscript.