Odor and purinergic receptor (P2R) agonists evoke increases in [Ca2+]i. See also supplementary information (available at http://medstat.med.utah.edu/physio/hegg/). A1–D4, Confocal images from a fluo-4-AM-loaded mouse OE slice during application of odors (10 μM n-amyl acetate + 10 μM R-carvone) (A), 10 μM ATP (B), 10 μM βγ-methylene ATP (βγ-MeATP) (C), or 10 μM UTP (D). Scale bar, 10 μm. A5–D5, Time course of odor- and P2R-agonist-evoked Ca2+ transients. Time points indicated by black triangles correspond to frame numbers in A1–D4. Representative odor-responsive ORNs are indicated by filled triangles (A1–A4; 6/11 ORNs marked) and as solid lines in A5. One odor-responsive ORN (filled triangle in B1–D4) and one SC (open triangle in B1–D4) are shown in the time course (B5–D5).