Table 2.

Univariate Logistic Regression of HIV Shedding in Saliva

Variable	Salivary HIV-1 Shedding	OR (95% CI)	p-value
Alcohol use in last 6 months
No	71/207 (34)a	1.00
Yes	68/143 (48)	1.57 (0.97 – 2.54)	0.07
Drug use in last 6 months (crack, cocaine, heroin, IDU)
No	117/318 (37)	1.00
Yes	22/34 (65)	2.87 (1.08 – 7.63)	0.03
Diabetes
No	131/338 (39)	1.00
Yes	9/15 (60)	2.75 (0.95 – 7.99)	0.06
AIDS
No	90/247 (36)	1.00
Yes	51/107 (48)	1.59 (0.95 – 2.68)	0.08
ARV therapy at study visit
None	57/96 (59)	1.00	0.0002b
Mono/Combo	17/45 (38)	0.32 (0.14 – 0.75)
HAART	66/212 (31)	0.28 (0.16 – 0.48)
CD4+ cell count
500+	37/139 (27)	1.00	<.0001b
350–499	27/84 (32)	1.38 (0.75 – 2.53)
200–349	37/65 (57)	3.56 (1.76 – 7.20)
<200	39/62 (63)	4.72 (2.46 – 9.06)
HIV-1 RNA in plasma
<1,000	39/202 (19)	1.00	<.0001b
1,000 – 9,999	34/67 (51)	4.16 (2.15 – 8.08)
10,000+	67/81 (83)	19.6 (10.3 – 37.3)
Plaque
No or probe only	17/57 (30)	1.00
Visible	111/273 (41)	1.57 (0.93 – 2.68)	0.09
Average gingival banding
None	111/303 (37)	1.00
Present	17/27 (63)	2.22 (0.97 – 5.10)	0.06
Decayed filled root surfaces
None	103/278 (37)	1.00
Present	29/57 (51)	1.64 (0.91 – 2.96)	0.10
Stimulated salivary flow rate, mL/min c
Positive for shedding d	0.67 (0.67) d	0.67 (0.46 – 0.98)	0.04
No shedding	0.83 (0.75)
Proportion of teeth with plaque visible c
Positive for shedding d	0.25 (0.40) d	2.08 (0.93 – 4.66)	0.08
No shedding	0.19 (0.39)
Proportion of bleeding sites c
Positive for shedding d	0.20 (0.30) d	4.28 (1.59 – 11.5)	.004
No shedding	0.14 (0.24)
Visit c		1.16 (1.07 – 1.25)	0.0003 b

Table includes independent variables associated with salivary shedding at p≤0.10. Parameter estimates and significance tests are from logistic regression with generalized estimating equations.

^aNo. of visits with salivary shedding/total visits (percent)

^bP-value for trend

^cORs for continuous variables are based on a one unit change in the predictor; for study visit, one unit change = 6 months

^dMedian(IQR) by salivary shedding status