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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Brain Behav Immun. 2010 Oct 8;25(5):922–931. doi: 10.1016/j.bbi.2010.10.002

Figure 7.

Figure 7

MOG-specific T cell cytokine production in CXCL13+/+ and CXCL13−/−-mice during active immunization EAE. ELISpot assays were used to enumerate the number of splenic T cells producing each cytokine ex vivo following stimulation with MOG35–55 At peak disease, cells producing both IFN-γ (Th1) and IL-17 (Th17) were present in equivalent numbers in both hosts (A). Two weeks later, both Th1 and Th17 responses had waned in the CXCL13−/−-mice compared to the CXCL13+/+ controls * p < 0.05 by Student’s t-test for the indicated cytokines compared to CXCL13+/+ controls. All bars represent the mean ± SEM of numbers measured from at least triplicate samples.