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. Author manuscript; available in PMC: 2012 Apr 4.
Published in final edited form as: J Neurosci. 2010 Oct 27;30(43):14513–14521. doi: 10.1523/JNEUROSCI.4025-10.2010

Figure 6.

Figure 6

Decreased tactile stimulation leads to ventral migration and transdifferentiation of DRG neurons. A, 4 dpf embryos raised under conditions that decrease tactile stimulation show a reduced touch response compared to embryos raised under control or increased stimulation conditions (**p<0.001 versus control and increased stimulation, Kruskal-Wallis; sample size ranged between 10 and 65 embryos). B, Decreased tactile stimulation increases the number of ectopic DRG neurons at 4 dpf (*p=0.02 versus control, Mann-Whitney U-test; sample size ranged between 20 and 50 embryos). C, At 11 dpf, a subset of migratory DRG neurons (arrowhead) expresses the sympathetic marker TH (green). HuA immunoreactivity is shown in red; white lines demarcate the dorsal and ventral boundaries of the notochord; arrows indicate normally-positioned DRG neurons. The fraction of migratory DRG neurons expressing TH does not differ significantly between control (9/35; 14 embryos), increased stimulation (17/58; 16 embryos) and sensory deprived embryos (16/47; 13 embryos). Scale bar, 40 μm.