Skip to main content
. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Cell Cycle. 2010 Oct 10;9(20):4061–4067. doi: 10.4161/cc.9.20.13579

Figure 1.

Figure 1

Mammalian Rap1 resembles yeast and trypanosome Rap1. Top: the mammalian shelterin complex and its role in repressing HDR at chromosome ends. Schematic representation of the conserved protein motifs of Rap1 and its TRF2-like partners in the indicated organisms. MYB indicates regions with a MYB sequence. Myb-fold indicates a motif that lacks sequence similarity to the MYB sequence but has a similar fold. The cyan boxes in Rap1 of S. pombe and T. brucei indicate that while these proteins have sequence similarity to the Myb-fold of S. cerevisiae, their structure has not been determined. It is not known whether Rap1 of S. pombe and T. brucei have an RCT domain but the C-terminus of T. brucei Rap1 is not required for its interaction with its TRF interacting partner.