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. Author manuscript; available in PMC: 2011 Jan 21.
Published in final edited form as: Clin Epigenetics. 2010 Dec 1;1(3-4):101–116. doi: 10.1007/s13148-010-0011-5

Fig. 1.

Fig. 1

Schematic diagram illustrating DNA methylation catalyzed by DNMTs. a The DNA methylation process is catalyzed by the DNMTs by adding a methyl group (CH3) from SAM to the 5-position of the cytosine ring. SAM donates a methyl group and is then converted into SAH. b Methylated cytosine moieties in CpG dinucleotides within a gene promoter. c DNMTs convert unmethylated DNA into methylated DNA in chromatin. White circles unmethylated CpG sites, green circles hypermethylated CpG sites, yellow circles histone proteins, red thread DNA