Table 1.
Class I/II and IV HDACs; cellular localization and cancer association
| HDAC | Localization | Deregulation in cancer | Tumor |
|---|---|---|---|
| Class I | |||
|
| |||
| HDAC1 | Nucleus | Overexpression/underexpression | Esophageal, colon, prostate, CTCL |
| HDAC2 | Nucleus | Overexpression/mutation | Prostate, colon, gastric, endometrial, CTCL |
| HDAC3 | Nucleus | Overexpression | Prostate, colon |
| HDAC8 | Nucleus | Overexpression | Colon |
|
| |||
| Class IIa | |||
|
| |||
| HDAC4 | Nucleus/Cytoplasm | Overexpression/underexpression/ mutation |
Prostate, colon, breast |
| HDAC5 | Nucleus/Cytoplasm | Underexpression | Colon, AML |
| HDAC7 | Nucleus/Cytoplasm | Overexpression | Colon |
| HDAC9 | Nucleus/Cytoplasm | Overexpression/underexpression | Medulloblastomas, astrocytomas |
|
| |||
| Class IIb | |||
|
| |||
| HDAC6 | Predominantly Cytoplasm | Overexpression | Breast, AML, CTCL |
| HDAC10 | Predominantly Cytoplasm | Overexpression | Heptocellular Carcinoma |
|
| |||
| Class IV | |||
|
| |||
| HDAC11 | Nucleus/Cytoplasm | Overexpression | Breast |