Table 3.
Apoptotic and Autophagy related genes regulated by HDACI.
| Biological effect/gene | Pathway | Effect on gene transcription by HDAC inhibition [reference] |
|---|---|---|
| Autophagy | ||
|
| ||
| Beclin-1 | Aggresome | Up-regulated [86] |
| ATG-7 | Aggresome | Up-regulated [86] |
|
| ||
| ROS production/activity | ||
|
| ||
| TBP2 | ROS | Up-regulated [104] |
| Thioredoxin | ROS | Up-regulated [104] |
|
| ||
| Apoptosis | ||
|
| ||
| TRAIL | Extrinsic apoptosis | Up-regulated [105-108] |
| DR5 | Extrinsic apoptosis | Up-regulated [105-108] |
| DR4 | Extrinsic apoptosis | Up-regulated [109] |
| Fas | Extrinsic apoptosis | Up-regulated [106, 110] |
| FasL | Extrinsic apoptosis | Up-regulated [106, 110] |
| TNFα | Extrinsic apoptosis | Up-regulated [111] |
| c-FLIP | Extrinsic apoptosis | Down-regulated [101, 103] |
| Bcl2 | Intrinsic apoptosis | Down-regulated [112] |
| BclXL | Intrinsic apoptosis | Down-regulated [31, 113] |
| Bclw | Intrinsic apoptosis | Down-regulated [114] |
| Mcl-1 | Intrinsic apoptosis | Down-regulated [31, 113] |
| XIAP | Intrinsic apoptosis | Down-regulated [115, 116] |
| Caspase-3 | Intrinsic apoptosis | Up-regulated [31] |
| Apaf-1 | Intrinsic apoptosis | Up-regulated [31] |
| Bak | Intrinsic apoptosis | Up-regulated [31, 104, 113] |
| Bid | Intrinsic apoptosis | Up-regulated/cleaved [116-118] |
| Bim | Intrinsic apoptosis | Up-regulated/phosphorylated [104, 113, 118-120] |
| Bmf | Intrinsic apoptosis | Up-regulated [104, 121] |
| Bax | Intrinsic apoptosis | Up-regulated/phosphorylated [119] |
| Noxa | Intrinsic apoptosis | Up-regulated [120] |
| Puma | Intrinsic apoptosis | Up-regulated [122] |
| AVEN | Intrinsic apoptosis | Down-regulated [63] |
| Survivin | Intrinsic/Extrinsic apoptosis | Down-regulated [123] |