While wildtype mice exhibit an increase in Fos protein in the ventral (a) and dorsal (b) BNST, lateral septum (c), and the nucleus accumbens shell (d) in response to forced swim stress, CREBαΔ mutant mice do not. This decreased stress response is not seen in the nucleus accumbens core (e), lateral hypothalamus (f), prelimbic cortex (g), or infralimbic cortex (h). No differences were seen between the genotypes in response to an acute cocaine injection (a-h). *p<.05, **p<.01, ***p<.001 as compared to control; #p<.05 pair-wise comparison wildtype FST vs. mutant FST.