Figure 10. Stress-induced reinstatement requires BNST activation.
A. Vehicle- and lidocaine-treated mice exhibit similar levels of preference for the cocaine-paired side on the posttest day compared to their preferences prior to conditioning and similar levels of extinction. However, on reinstatement test day, only vehicle-treated animals exhibit a significant preference for the drug-paired side. **p<.01, extinction vs. reinstatement; ***p<.001, posttest vs. pretest. B. Microinjector placements within the BNST for all cocaine-conditioned animals.