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. Author manuscript; available in PMC: 2012 Feb 9.
Published in final edited form as: Structure. 2011 Feb 9;19(2):155–161. doi: 10.1016/j.str.2010.12.007

Figure 1. Scheme of cross-crystal averaging to determine the structure of SARS coronavirus receptor-binding domain (scRBD) complexed with human ACE2.

Figure 1

The masks covering the two lobes of the ACE2 in the reference molecule (scRBD-ACE2 complex) are shown in red and blue, respectively. The matrices that move the reference molecule to the NCS-related molecule and the molecules in the second crystal are indicated by arrows. An additional mask is generated to generously cover the missing scRBD domain in the reference molecule. The boundary of this mask is also drawn in dashed lines in the NCS related molecule.