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. Author manuscript; available in PMC: 2011 Jul 5.
Published in final edited form as: J Neurosci. 2011 Jan 5;31(1):78–88. doi: 10.1523/JNEUROSCI.3542-10.2011

Figure 4. Co-expression of TH with other molecular markers during development of the VSC.

Figure 4

GABA, NPY, or GABA/NPY are co-expressed in distinct regions of the VSC during development. A. Some TH+ cells in the core region (inner dashed circle) co-express GABA (arrow) while others are GABA− (arrowheads). TH+ neurons in the annular region are TH+/GABA+/NPY+ (outer dashed circle, open arrows). Graph shows developmental changes in proportions of GABA and NPY co-expression with TH. B. TH+ cells of the outer annular region co-express GABA and Nurr1 (arrows). This brain section depicts a more caudal region of the VSC. Graph shows the proportion of TH co-expression with GABA and Nurr1. C. TH+ cells of the core all co-express Lim1,2 (arrowheads), but some are also GABA+ (arrows), while the TH+ cells in the annulus co-express Lim1,2 and GABA (arrows). Cells in the outer annular region are Lim1,2− but co-express TH and GABA (open arrows). Graph shows the proportion of TH co-expression with GABA and Lim1,2. A–C. Images are from stage 42 larvae. Scale bars in A apply to all figures in each column and are 80 µm for the first column and 40 µm for the second and third columns. Values are mean ± SEM for N≥4 larvae per stage.