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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Neuropsychopharmacology. 2011 Feb 16;36(6):1260–1274. doi: 10.1038/npp.2011.12

Figure 3.

Figure 3

Similar to clozapine, acute treatment of the mGluR2/3 agonist LY379268 enhances NMDA receptor functions in normal rat PFC. (A) Representative Western blot images of the expression of NR2A, NR2B, pNR2B Ser1303, and actin. (B) Summary histogram showing the similar and significant enhancing effects of clozapine (5 mg/kg, i.p) and LY379268 on the expressions of NR2 subunits and pNR2B Ser1303 (P < 0.05). Overall, it appeared that the increases in NR2A proteins were more than those in NR2B for all drug treatments (P < 0.05). The total protein level of NR2A was particularly upregulated by high-dose LY379268 (3.0 mg/kg) compared with that of low-dose LY379268 (0.3 mg/kg) and clozapine (P < 0.05).