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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Neuropsychopharmacology. 2011 Feb 16;36(6):1260–1274. doi: 10.1038/npp.2011.12

Figure 4.

Figure 4

LY379268 enhances NMDA-mediated current. (A) Bath-applied NMDA (15 µM) induced stable inward current when recorded at −60 mV in the presence of CNQX (20 µM) and picrotoxin (50 µM) with regular Ringer’s solution. Bath application of LY379268 (300 nM) dramatically and significantly increased the NMDA-induced current by an average of 48.6 ± 14.7% (n = 4, P < 0.05). (B) Puff-NMDA-induced currents were also dramatically and significantly increased by LY379268 (300 nM bath) for 53.1 ± 13.0% (n = 5, P < 0.01).